A biorefinery is an efficient approach to generate multiple bio-products from biomass. With the increasing de- mand for bioenergy and bio-products, biorefineries are essential industrial platforms that provide needed de- mand while significantly reducing greenhouse gas emissions. A biorefinery consists of various conversion technologies where particulate matter (PM) and volatile organic compounds (VOCs) are emitted. The released PM and VOCs pose detrimental health and environmental risks for society. Moreover, the projected rise of global bioenergy demand may lead to an increase in PM and VOCs from biorefineries. With the use of cleaner tech- nologies and approaches, PM and VOCs can be avoided in biorefineries. The study presents the landscape of the research field through a bibliometric review of emissions from a biorefinery. A comprehensive review of works on the reduction of PM and VOCs in a biorefinery is outlined. The study includes a perspective of cleaner technologies and approaches utilized in biorefineries to mitigate these hazardous materials. The results reveal that the employment of life cycle assessment, safety assessment, and green chemistry processes can significantly reduce PM and VOC emissions as well as the consumption of hazardous substances in the biorefinery.