2013 |
Journal Articles |
Keating, Peter; Cambrosio, Alberto; Nelson, Nicole; Mogoutov, Andrei; Cointet, Jean-Philippe Therapy’s shadow: a short history of the study of resistance to cancer chemotherapy Journal Article Frontiers in pharmacology, 4 , pp. 58, 2013. Abstract | Links | BibTeX @article{keating2013therapy,
title = {Therapy’s shadow: a short history of the study of resistance to cancer chemotherapy},
author = {Peter Keating and Alberto Cambrosio and Nicole Nelson and Andrei Mogoutov and Jean-Philippe Cointet},
url = {https://doi.org/10.3389/fphar.2013.00058},
year = {2013},
date = {2013-01-01},
journal = {Frontiers in pharmacology},
volume = {4},
pages = {58},
publisher = {Frontiers},
abstract = {This article traces the history of research on resistance to drug therapy in oncology using scientometric techniques and qualitative analysis. Using co-citation analysis, we generate maps to visualize subdomains in resistance research in two time periods, 1975–1990 and 1995–2010. These maps reveal two historical trends in resistance research: first, a shift in focus from generic mechanisms of resistance to chemotherapy to a focus on resistance to targeted therapies and molecular mechanisms of oncogenesis; and second, a movement away from an almost exclusive reliance on animal and cell models and toward the generation of knowledge about resistance through clinical trial work. A close reading of highly cited articles within each subdomain cluster reveals specific points of transition from one regime to the other, in particular the failure of several promising theories of resistance to be translated into clinical insights and the emergence of interest in resistance to a new generation of targeted agents such as imatinib and trastuzumab. We argue that the study of resistance in the oncology field has thus become more integrated with research into cancer therapy – rather than constituting it as a separate domain of study, as it has done in the past, contemporary research treats resistance as the flip side to treatment, as therapy’s shadow.},
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This article traces the history of research on resistance to drug therapy in oncology using scientometric techniques and qualitative analysis. Using co-citation analysis, we generate maps to visualize subdomains in resistance research in two time periods, 1975–1990 and 1995–2010. These maps reveal two historical trends in resistance research: first, a shift in focus from generic mechanisms of resistance to chemotherapy to a focus on resistance to targeted therapies and molecular mechanisms of oncogenesis; and second, a movement away from an almost exclusive reliance on animal and cell models and toward the generation of knowledge about resistance through clinical trial work. A close reading of highly cited articles within each subdomain cluster reveals specific points of transition from one regime to the other, in particular the failure of several promising theories of resistance to be translated into clinical insights and the emergence of interest in resistance to a new generation of targeted agents such as imatinib and trastuzumab. We argue that the study of resistance in the oncology field has thus become more integrated with research into cancer therapy – rather than constituting it as a separate domain of study, as it has done in the past, contemporary research treats resistance as the flip side to treatment, as therapy’s shadow. |
Raimbault, Benjamin; Cointet, Jean-Philippe; Joly, Pierre-Benoît Caractérisation du processus d’émergence de la biologie synthétique à partir d’une approche scientomiétrique Journal Article médecine/sciences, 29 , pp. 47-55, 2013. Abstract | Links | BibTeX @article{raimbault2013caracterisation,
title = {Caractérisation du processus d’émergence de la biologie synthétique à partir d’une approche scientomiétrique},
author = {Benjamin Raimbault and Jean-Philippe Cointet and Pierre-Benoît Joly},
url = {https://doi.org/10.1051/medsci/201329s213},
year = {2013},
date = {2013-01-01},
journal = {médecine/sciences},
volume = {29},
pages = {47-55},
publisher = {Éditions EDK, Groupe EDP Sciences},
abstract = {La biologie de synthèse est un espace hétérogène dont la définition n’est pas stabilisée. Elle se situe à l’intersection de différents champs disciplinaires : chimie, biologie moléculaire, bio-informatique, et est classiquement abordée par la littérature selon trois angles [1–3] : 1 une approche « DNA based device construction » (biobrick), ou approche bottom-up, focalisée sur l’ingénierie de circuits de gènes synthétiques ; 2 une approche « genome-driven cell engineering », ou approche top-down, focalisée sur la synthèse d’un génome dans son intégralité ; 3 une approche « proto-cell creation » qui vise à recréer des systèmes cellulaires minimaux, et en vertu de laquelle les recherches sont focalisées sur le principe de l’émergence, ouvertement présenté comme un obstacle par les tenants de la première approche.
},
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La biologie de synthèse est un espace hétérogène dont la définition n’est pas stabilisée. Elle se situe à l’intersection de différents champs disciplinaires : chimie, biologie moléculaire, bio-informatique, et est classiquement abordée par la littérature selon trois angles [1–3] : 1 une approche « DNA based device construction » (biobrick), ou approche bottom-up, focalisée sur l’ingénierie de circuits de gènes synthétiques ; 2 une approche « genome-driven cell engineering », ou approche top-down, focalisée sur la synthèse d’un génome dans son intégralité ; 3 une approche « proto-cell creation » qui vise à recréer des systèmes cellulaires minimaux, et en vertu de laquelle les recherches sont focalisées sur le principe de l’émergence, ouvertement présenté comme un obstacle par les tenants de la première approche.
|
Inproceedings |
Massad, D; Omodei, Elisa; Strohecker, Carol; Xu, Yiqun; Garland, Joshua; Zhang, Mengsen; Seoane, Luís F Unfolding History: Classification and analysis of written history as a complex system Inproceedings Complex Systems Summer School Proceedings, 2013. Abstract | Links | BibTeX @inproceedings{massad2013unfolding,
title = {Unfolding History: Classification and analysis of written history as a complex system},
author = {D Massad and Elisa Omodei and Carol Strohecker and Yiqun Xu and Joshua Garland and Mengsen Zhang and Luís F. Seoane},
url = {https://www.semanticscholar.org/paper/Unfolding-History-%3A-Classification-and-analysis-of-Massad-Omodei/909983164867fd53a1d934e13c1cd6a4b6c51ba3},
year = {2013},
date = {2013-01-01},
booktitle = {Complex Systems Summer School Proceedings},
abstract = {Before writing, chronicles were told by word of mouth. They conveyed information of important historic events that could readily be mixed up with legends–or become them. Chronicles needed to be easily accessible for people to pass them along, and stories lived on in listeners’ short memories. This collective, ever-waning awareness was the technology that kept the tales extant, and this technology required a continuous effort in reminding people never to forget. This way of keeping stories alive also imposed important constrains on the kind and form of the narrative material. Breathtaking epics were perhaps more likely to survive, which could easily tend toward mystification of pre-historic characters. These epics had to be kept in the form of repetitive, easy-to-learn patterns. It comes as a pleasant surprise for us that diverse ancient poems take similar},
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pubstate = {published},
tppubtype = {inproceedings}
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Before writing, chronicles were told by word of mouth. They conveyed information of important historic events that could readily be mixed up with legends–or become them. Chronicles needed to be easily accessible for people to pass them along, and stories lived on in listeners’ short memories. This collective, ever-waning awareness was the technology that kept the tales extant, and this technology required a continuous effort in reminding people never to forget. This way of keeping stories alive also imposed important constrains on the kind and form of the narrative material. Breathtaking epics were perhaps more likely to survive, which could easily tend toward mystification of pre-historic characters. These epics had to be kept in the form of repetitive, easy-to-learn patterns. It comes as a pleasant surprise for us that diverse ancient poems take similar |
Bahi-Jaber, Narges; Mogoutov, Andrei; Elmhiri, Ghada; Abdennebi-Najar, Latifa Animal models and fetal programming: an integrativeliterature approach Inproceedings Journal of Developmental Origins of Health and Disease, 8th World Congress on Developmental Origins of Health and Disease, pp. 54-55, 2013. Abstract | Links | BibTeX @inproceedings{park20138th,
title = {Animal models and fetal programming: an integrativeliterature approach},
author = {Narges Bahi-Jaber and Andrei Mogoutov and Ghada Elmhiri and Latifa Abdennebi-Najar},
url = {https://www.researchgate.net/profile/Venkata_Malakapalli/publication/311847383_Modelling_developmental_origins_of_adult_based_diseases_obesity_using_mesenchymal_stem_-_cellular_molecular_and_functional_approaches/links/585d476308aebf17d38a31b8/Modelling-developmental-origins-of-adult-based-diseases-obesity-using-mesenchymal-stem-cellular-molecular-and-functional-approaches.pdf},
year = {2013},
date = {2013-01-01},
booktitle = {Journal of Developmental Origins of Health and Disease, 8th World Congress on Developmental Origins of Health and Disease},
journal = {Journal of Developmental Origins of Health and Disease},
volume = {4},
number = {2},
pages = {54-55},
abstract = {Despite the substantial epidemiological evi-dence for fetal origins of adult disease, there are intrinsiclimitations in long-term retrospective studies. Some aspectscan, however, be focused on by using the controlledconditions afforded by animal models, a number of whichhave been developed to study thisin uteroprogrammingphenomenon. Animal models allow study of the pathophy-siology of disease, and afford a means to study the underlyingbiochemical and molecular biological mechanisms, whilstthey cannot be used entirely as a substitute for the study ofhuman diseases. Analyzing the contribution of animal modelsin our understanding of fetal programming as well as theirlimits requires a systematic review of the existing literature.},
keywords = {},
pubstate = {published},
tppubtype = {inproceedings}
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Despite the substantial epidemiological evi-dence for fetal origins of adult disease, there are intrinsiclimitations in long-term retrospective studies. Some aspectscan, however, be focused on by using the controlledconditions afforded by animal models, a number of whichhave been developed to study thisin uteroprogrammingphenomenon. Animal models allow study of the pathophy-siology of disease, and afford a means to study the underlyingbiochemical and molecular biological mechanisms, whilstthey cannot be used entirely as a substitute for the study ofhuman diseases. Analyzing the contribution of animal modelsin our understanding of fetal programming as well as theirlimits requires a systematic review of the existing literature. |
